On December 7, 2016, the US Congress enacted the 21st Century Cures Act, substantial legislation intended to accelerate “discovery, development and delivery” of medical therapies by encouraging biomedical research investment, facilitating innovation review and approval processes, and continuing to invest in and modernize the delivery of health care. The massive bill also serves as a vehicle for a variety of other health-related measures. President Obama signed the Cures Act on December 13, 2016. This series of articles looks closely at several sections of the legislation, offering an examination of the provisions included therein and suggestions for implementation.