Hospitals and health systems (HHS) are increasingly acting as the catalyst for growth and expansion through technology and data innovations. Through their centralized initiatives, HHSs not only drive internal innovation, but also allow HHSs to explore external investment opportunities and collaborations with third parties. As an HHS considers these funding opportunities, it must also ensure that it is conducting appropriate and thorough due diligence. Particularly when investing in start-up companies to develop and commercialize innovative products, HHSs need to tackle due diligence through a fresh lens. In the fifth installment of our Focus on Innovation Centers series, Kerrin Slattery and Kristian Werling explore the need for specialized due diligence for Innovation Centers and three key areas to focus on to maximize the value of such investments.